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Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia

5 Sept 2016

Abstract excerpt

Upfront resistance to chemotherapy and relapse following remission are critical problems in leukemia that are generally attributed to subpopulations of chemoresistant tumor cells. There are, however, limited means for prospectively identifying these subpopulations, which hinders an understanding of therapeutic resistance. BH3 profiling is a functional single-cell analysis using synthetic BCL-2 BH3 domain-like...

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PMID: 27599292
DOI: 10.1172/jci82908

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