Article

Upregulation of Genetic Markers of Poor Prognosis following Chemotherapy in Acute Myeloid Leukemia Cells

2026-02-15

Abstract excerpt

Chemoresistance, a leading cause of treatment failure in cancer, is commonly explained by Darwinian selection of treatment-resistant cell clones. However, recurring resistant tumors invariably display complex phenotypes that contribute to increased malignancy, unlikely to have been selected for by chemotherapy. The growing awareness of (non - genetic) phenotypic plasticity led to the hypothesis that chemotherapy,...

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Literature Corpus work: f1ba1e46-9b31-5550-9642-a3d79b78bee3
DOI: 10.64898/2026.02.12.705420

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