Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy

29 Jun 2018

Abstract excerpt

Abstract The identification of new therapeutic strategies against osteosarcoma, the most common primary bone tumor, continues to be a primary goal to improve the outcomes of patients refractory to conventional chemotherapy. Osteosarcoma originates from the transformation of mesenchymal stem cells (MSC) and/or osteoblast progenitors, and the loss of differentiation is a common biological osteosarcoma feature,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29959201
DOI: 10.1158/1535-7163.mct-17-0818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma TherapyPMID 29959201Read ↗

Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cellsSemantic proximity Read ↗

A novel small-molecule antagonist enhances the sensitivity of osteosarcoma to cabozantinib in vitro and in vivo by targeting DNMT-1 correlated with disease severity in human patientsSemantic proximity Read ↗

Deletion ofMTAPHighly Sensitizes Osteosarcoma Cells to Methionine Restriction With Recombinant MethioninaseSemantic proximity Read ↗

Theabrownin triggers DNA damage to suppress human osteosarcoma U2 OS cells by activating p53 signalling pathwaySemantic proximity Read ↗

Overcoming Glutathione <i>S</i> -Transferase P1–Related Cisplatin Resistance in OsteosarcomaSemantic proximity Read ↗

Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53‐dependent pathwaySemantic proximity Read ↗

Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivoSemantic proximity Read ↗

Arginine Methylation of hnRNPK Inhibits the DDX3-hnRNPK Interaction to Play an Anti-Apoptosis Role in Osteosarcoma Cells.Semantic proximity Read ↗

Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cellsSemantic proximity Read ↗

A novel synthetic microtubule inhibitor exerts antiproliferative effects in multidrug resistant cancer cells and cancer stem cellsSemantic proximity Read ↗

TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma modelSemantic proximity Read ↗

Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.