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Article

miR-132 regulates the expression of synaptic proteins in APP/PS1 transgenic mice through C1q

3 May 2019

Abstract excerpt

Cognitive impairment in Alzheimer's disease (AD) is usually accompanied by synaptic loss in both the hippocampus and neocortex. In the early stage of AD, amyloid β-induced synapse changes is the main reason, while in the later stage, the accumulation of Tau protein promotes synapse degeneration as the key factor leading to dementia. MicroRNA (miRNA) is closely related to the expression changes of many AD-related...

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PMID: 31060348
DOI: 10.4081/ejh.2019.3008

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