Multifaceted Suppression of Staphylococcal Virulence Phenotypes: In Vitro Study of a Cellular Status With Reduced Agr Activity and Impaired Biofilm.

doi:10.1002/mbo3.70380

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Article

Multifaceted Suppression of Staphylococcal Virulence Phenotypes: In Vitro Study of a Cellular Status With Reduced Agr Activity and Impaired Biofilm.

MicrobiologyOpen - 1 Oct 2026

Nguyen Nghi Bao, Ushijima Yuri, Sekiya Raiku, Morikawa Kazuya, Nguyen Le Thuy Thi

Abstract excerpt

Anti-quorum sensing (QS) therapy has been focused on to reduce the virulence of pathogenic bacteria. However, there is a risk that suppression of the staphylococcal QS Agr system might promote biofilm formation. In this study, we found that both Agr activity and the biofilm of Staphylococcus aureus can be reduced by a sappanwood extract (SWe). The impaired biofilm in the presence of SWe exhibited reduced...

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Topics

Biofilms
Staphylococcus aureus
Bacterial Proteins
Trans-Activators
Virulence
Virulence Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Expression Regulation, Bacterial

Quorum Sensing

Phenotype

Staphylococcal Infections

Anti-Bacterial Agents

Protein Kinases

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 42733210
DOI: 10.1002/mbo3.70380
PMCID: PMC13572819

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