Quorum sensing-mediated regulation of staphylococcal virulence and antibiotic resistance.

doi:10.2217/fmb.14.31

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Article

Quorum sensing-mediated regulation of staphylococcal virulence and antibiotic resistance.

Future microbiology - 1 Jan 2014

Singh Rachna, Ray Pallab

Abstract excerpt

Accessory gene regulator (agr)-mediated quorum sensing plays a central role in staphylococcal pathogenesis. It primarily upregulates secreted virulence factors and downregulates cell surface proteins, thereby governing invasiveness of staphylococci and cell dispersal from biofilms. Except for α- and β-PSMs, which are directly controlled by AgrA, the effector functions of agr are primarily mediated by RNAIII, a...

Topics

Bacterial Proteins
Biodiversity
Biofilms
Drug Resistance, Multiple, Bacterial
Gene Expression Regulation, Bacterial
Genetic Variation
Hemolysin Proteins
Quorum Sensing
Staphylococcal Infections
Staphylococcus aureus
Staphylococcus epidermidis
Trans-Activators
Virulence Factors

Source

Open in PubMed

Identifiers

PMID: 24957093
DOI: 10.2217/fmb.14.31

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