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Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities

25 Apr 2019

Abstract excerpt

We performed the first proteogenomic study on a prospectively collected colon cancer cohort. Comparative proteomic and phosphoproteomic analysis of paired tumor and normal adjacent tissues produced a catalog of colon cancer-associated proteins and phosphosites, including known and putative new biomarkers, drug targets, and cancer/testis antigens. Proteogenomic integration not only prioritized genomically inferred...

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PMID: 31031003
DOI: 10.1016/j.cell.2019.03.030

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