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The Plasticity of Mesenchymal Stem Cells in Regulating Surface HLA-I

11 Apr 2019

Abstract excerpt

A low surface expression level of human leukocyte antigen class I (HLA-I) ensures that the mesenchymal stem cells (MSCs) escape from the allogeneic recipients' immunological surveillance. Here, we discovered that both transcriptional and synthesis levels of HLA-I in MSCs increased continuously after interferon (IFN)-γ treatment, whereas interestingly, their surface HLA-I expression was downregulated after...

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PMID: 31030183
DOI: 10.1016/j.isci.2019.04.011

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