Article

The Impact of IFN-γ Licensing on Mesenchymal Stromal Cells Mediated Immunoregulation and HLA Class II Expression: Emerging Evidence from In Vitro Results

2025-08-26

Abstract excerpt

<h4>Background: </h4> Mesenchymal Stromal Cells (MSCs) exert their immunoregulatory properties after licensing by inflammatory signaling cues, e.g. interferon (IFN)-γ. However, MSCs licensing by IFN-γ may result in increased expression of Human Leukocyte Antigens (HLA) class II, which is related to rapid cell elimination, impairment of their immunosuppressive properties and patient sensitization. The aim of this s...

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Literature Corpus work: 44721899-c7ae-59cf-ab40-d2b6f8ee7de7
DOI: 10.20944/preprints202508.1799.v1

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