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Article

TMEM173 Alternative Spliced Isoforms Modulate Viral Replication through the STING Pathway

1 Dec 2018

Abstract excerpt

Abstract The innate immune system provides a primary line of defense against pathogens. Stimulator of IFN genes (STING), encoded by the TMEM173 gene, is a critical protein involved in IFN-β induction in response to infection by different pathogens. In this study, we describe the expression of three different alternative-spliced human (h) TMEM173 mRNAs producing STING truncated isoforms 1, 2, and 3 in addition to...

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PMID: 31026807
DOI: 10.4049/immunohorizons.1800068

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