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Article

Multiplex Solid-Phase Melt Curve Analysis for the Point-of-Care Detection of HIV-1 Drug Resistance.

The Journal of molecular diagnostics : JMD - 1 Jul 2019

Clutter Dana S, Mazarei Gelareh, Sinha Ruma, Manasa Justen, Nouhin Janin, LaPrade Ellen, Bolouki Sara, Tzou Philip L, Hannita-Hui Jessica, Sahoo Malaya K, Kuimelis Peter, Kuimelis Robert G, Pinsky Benjamin A, Schoolnik Gary K, Hassibi Arjang, Shafer Robert W

Abstract excerpt

A point-of-care HIV-1 genotypic resistance assay that could be performed during a clinic visit would enable care providers to make informed treatment decisions for patients starting therapy or experiencing virologic failure on therapy. The main challenge for such an assay is the genetic variability at and surrounding each drug-resistance mutation (DRM). We analyzed a database of diverse global HIV sequences and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31026601
DOI: 10.1016/j.jmoldx.2019.02.005
PMCID: PMC6643098

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AGA

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