Article
Genetic Variability of HIV-1 for Drug Resistance Assay Development.
Viruses - 11 Feb 2016
Clutter Dana S, Rojas Sánchez Patricia, Rhee Soo-Yon, Shafer Robert W
Abstract excerpt
A hybridization-based point-of-care (POC) assay for HIV-1 drug resistance would be useful in low- and middle-income countries (LMICs) where resistance testing is not routinely available. The major obstacle in developing such an assay is the extreme genetic variability of HIV-1. We analyzed 27,203 reverse transcriptase (RT) sequences from the Stanford HIV Drug Resistance Database originating from six LMIC regions....
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