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Article

Genetic Variability of HIV-1 for Drug Resistance Assay Development.

Viruses - 11 Feb 2016

Clutter Dana S, Rojas Sánchez Patricia, Rhee Soo-Yon, Shafer Robert W

Abstract excerpt

A hybridization-based point-of-care (POC) assay for HIV-1 drug resistance would be useful in low- and middle-income countries (LMICs) where resistance testing is not routinely available. The major obstacle in developing such an assay is the extreme genetic variability of HIV-1. We analyzed 27,203 reverse transcriptase (RT) sequences from the Stanford HIV Drug Resistance Database originating from six LMIC regions....

Topics

Anti-HIV Agents
Base Sequence
Drug Evaluation, Preclinical
Drug Resistance, Viral
Genetic Variation
HIV Infections
HIV Reverse Transcriptase
HIV-1
Humans
Molecular Sequence Data
Mutation

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Identifiers

PMID: 26875985
DOI: 10.3390/v8020048
PMCID: PMC4776203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26875985-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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