Article
The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer.
Breast cancer research and treatment - 1 May 2010
Zhang H, Rakha E A, Ball G R, Spiteri I, Aleskandarany M, Paish E C, Powe D G, Macmillan R D, Caldas C, Ellis I O, Green A R
Abstract excerpt
The basal-like or basal phenotype (BP) class of breast cancers have recently attracted attention as a poor prognostic form of breast cancer. However, BP appears to encompass biologically and clinically heterogeneous tumours, resulting in a lack of consensus definition of BP. We analysed 48,000 gene transcripts in 132 invasive breast carcinomas to identify two novel genes (OATP2 and FABP7) significantly associated...
Topics
- Adult
- Biomarkers, Tumor
- Breast Neoplasms
- Carrier Proteins
- Disease-Free Survival
- Fatty Acid-Binding Protein 7
- Female
- Gene Expression
- Gene Expression Profiling
- Humans