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A DNA aptamer reveals an allosteric site for inhibition in metallo-β-lactamases

22 Apr 2019

Abstract excerpt

The hydrolysis of β-lactam antibiotics by β-lactamase enzymes is the most prominent antibiotic resistance mechanism for many pathogenic bacteria. Out of this broad class of enzymes, metallo-β-lactamases are of special clinical interest because of their broad substrate specificities. Several in vitro inhibitors for various metallo-β-lactamases have been reported with no clinical efficacy. Previously, we described...

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PMID: 31009467
DOI: 10.1371/journal.pone.0214440

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