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Article

Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics.

Journal of the American Chemical Society - 16 Jul 2014

Fishovitz Jennifer, Rojas-Altuve Alzoray, Otero Lisandro H, Dawley Matthew, Carrasco-López Cesar, Chang Mayland, Hermoso Juan A, Mobashery Shahriar

Abstract excerpt

Ceftaroline, a recently approved β-lactam antibiotic for treatment of infections by methicillin-resistant Staphylococcus aureus (MRSA), is able to inhibit penicillin-binding protein 2a (PBP2a) by triggering an allosteric conformational change that leads to the opening of the active site. The open...

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Identifiers

PMID: 24955778
DOI: 10.1021/ja5030657
PMCID: PMC4210145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24955778-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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