Back to search

Article

Covalent Inhibition of New Delhi Metallo-β-Lactamases NDM-1 and NDM-5 by 3-Bromopyruvate

2026-06-11

Abstract excerpt

Resistance to β-lactam antibiotics, including carbapenems, mediated by metallo-β-lactamases (MBLs), including the New Delhi metallo-β-lactamase (NDM) MBL subfamily, is increasing. No MBL inhibitors are currently approved for clinical use with most reported MBL inhibitors are metal ion chelators, acting either at the Zn(II) ion active site and/or in solution. The hexokinase inhibitor 3-bromopyruvate (3-BP) is repor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
06de4a95-0d3e-5632-b805-8c8136b77294
DOI
10.64898/2026.06.10.731408
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Covalent Inhibition of New Delhi Metallo-β-Lactamases NDM-1 and NDM-5 by 3-BromopyruvateDOI 10.64898/2026.06.10.731408
New Delhi Metallo-β-Lactamase-1: Structure, Inhibitors and Detection of ProducersSemantic proximity
New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and InhibitionSemantic proximity
Structure of New Delhi metallo-β-lactamase 1 (NDM-1)Semantic proximity
Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse and widespread in the environmentSemantic proximity
Crystal structure of New Delhi metallo‐β‐lactamase reveals molecular basis for antibiotic resistanceSemantic proximity
Enzyme Inhibitors: The Best Strategy to Tackle Superbug NDM-1 and Its Variants.Semantic proximity
A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamasesSemantic proximity
Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity.Semantic proximity
Molecular Basis of NDM-1, a New Antibiotic Resistance DeterminantSemantic proximity
Characterization of Purified New Delhi Metallo-β-lactamase-1Semantic proximity
β-Lactamases and β-Lactamase Inhibitors in the 21st CenturySemantic proximity
PHT427 as an effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor restored the susceptibility of meropenem against Enterobacteriaceae producing NDM-1Semantic proximity
Select a neighboring publication to make it the new centre.