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Article

E152A substitution drastically affects NDM-5 activity.

FEMS microbiology letters - 1 Feb 2017

Kumar Gaurav, Issa Bagre, Kar Debasish, Biswal Sarmistha, Ghosh Anindya S

Abstract excerpt

New Delhi Metallo beta-lactamase (NDM) is of significant public health concern due to its enormous potential to hydrolyse all major beta-lactams including carbapenems. Amino acid substitutions outside the active site reportedly affect NDM beta-lactamase activities. Here, the effect of amino acid substitutions in the possible omega-like loop region of NDM-5 has been elucidated. Overall, three substitution...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28087620
DOI: 10.1093/femsle/fnx008

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