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Article

Novel susceptibility genes for varicose veins revealed by a cross-tissue transcriptome-wide association study.

Science progress - 1 Jan 2026

Kuang Quanxing, Zhu Qingfeng, Li Xiaocheng, Yang Han, Jiang Wenhong, Wang Youfu, Qin Xiao

Abstract excerpt

ObjectiveTo identify susceptibility genes associated with varicose veins (VVs) using a cross-tissue transcriptome-wide association study (TWAS) framework.MethodsWe performed a cross-tissue TWAS by integrating GWAS data from the FinnGen R12 dataset (38,467 VVs cases and 432,223 controls of European ancestry) with eQTL data from GTEx V8. The initial analysis was conducted using the Unified Test for Molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 42333391
DOI: 10.1177/00368504261463907
PMCID: PMC13305478

Genes

POLR1B
PDK1
TMEM87B
MAP3K2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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