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The Absence of Parkin Does Not Promote Dopamine or Mitochondrial Dysfunction in PolgAD257A/D257AMitochondrial Mutator Mice

24 Oct 2022

Abstract excerpt

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). In this study, we generated a transgenic model by crossing germline Parkin–/–mice with PolgAD257Amice, an established model of premature aging and mitochondrial stress. We hypothesized that loss of Parkin–/–in PolgAD257A/D257Amice would exacerbate mitochondrial dysfunction,...

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PMID: 36280265
DOI: 10.1523/jneurosci.0545-22.2022

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