Article

Parkin is not required to sustain OXPHOS function in adult mammalian tissues

2023-09-02

Abstract excerpt

Loss-of-function variants in the PRKN gene encoding the ubiquitin E3 ligase PARKIN cause autosomal recessive early-onset Parkinson’s disease (PD). Extensive in vitro and in vivo studies have reported that PARKIN is involved in multiple pathways of mitochondrial quality control, including mitochondrial degradation and biogenesis. However, these findings are surrounded by substantial controversy due to conflictin...

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Identifiers and source

Literature Corpus work: d3737689-2caf-5c67-afcd-b33d12cb0e18
DOI: 10.1101/2023.09.02.556020

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