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Article

The HIF-1α and mTOR Pathways Amplify Heterotopic Ossification.

Biomolecules - 24 Jan 2024

Wang Haitao, Kaplan Frederick S, Pignolo Robert J

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP; MIM# 135100) is an ultra-rare congenital disorder caused by gain-of-function point mutations in the Activin receptor A type I (ACVR1, also known as ALK2) gene. FOP is characterized by episodic heterotopic ossification (HO) in skeletal muscles, tendons, ligaments, or other soft tissues that progressively causes irreversible loss of mobility. FOP mutations cause mild...

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Source

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Identifiers

PMID: 38397384
DOI: 10.3390/biom14020147
PMCID: PMC10887042

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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