Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Pan-Cancer Study of KMT2 Family as Therapeutic Targets in Cancer

11 Jan 2022

Abstract excerpt

OBJECTIVE: Exome sequencing studies have shown that the histone-lysine N-methyltransferase 2 (KMT2) gene is one of the most commonly mutated genes in a range of human malignancies and is linked to some of the most common and deadly solid tumors. However, the connection between this gene family's function and tumor type, immunological subtype, and molecular subtype dependency is still unknown. METHODS: We examine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35058979
DOI: 10.1155/2022/3982226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Pan-Cancer Study of KMT2 Family as Therapeutic Targets in CancerPMID 35058979Read ↗

KMT2C is Potential Prognostic Biomarker and its Immune Regulating Roles in Pan-Cancer: A Comprehensive AnalysisSemantic proximity Read ↗

Genomic alterations in KMT2 family predict outcome of immune checkpoint therapy in multiple cancersSemantic proximity Read ↗

Pan-Cancer Analysis of Histone Methyltransferase KMT2D with Potential Implications for Prognosis and Immunotherapy in Human CancerSemantic proximity Read ↗

Mutation status of the KMT2 family associated with immune checkpoint inhibitors (ICIs) therapy and implicating diverse tumor microenvironmentsSemantic proximity Read ↗

Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.Semantic proximity Read ↗

KMT2A/C mutations function as a potential predictive biomarker for immunotherapy in solid tumorsSemantic proximity Read ↗

Pan-Cancer Analysis Revealed ITM2A as a Predictive Biomarker of Prognosis and Immunotherapy for Kidney Renal Clear Cell CarcinomaSemantic proximity Read ↗

A Pan-Cancer Analysis Revealing the Dual Roles of Lysine (K)-Specific Demethylase 6B in Tumorigenesis and ImmunitySemantic proximity Read ↗

The role of KMT2 gene in human tumors.Semantic proximity Read ↗

Correlation of KMT2 family mutations with molecular characteristics and prognosis in colorectal cancer.Semantic proximity Read ↗

A comprehensive investigation discovered the novel methyltransferase METTL24 as one presumably prognostic gene for kidney renal clear cell carcinoma potentially modulating tumor immune microenvironmentSemantic proximity Read ↗

Large-scale analysis of KMT2 mutations defines a distinctive molecular subset with treatment implication in gastric cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.