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Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course

11 Apr 2019

Abstract excerpt

BACKGROUND: Multiple Sclerosis (MS) results from genetic predisposition and environmental variables, including elevated Body Mass Index (BMI) in early life. This study addresses the effect of BMI on the epigenome of monocytes and disease course in MS. METHODS: Fifty-four therapy-naive Relapsing Remitting (RR) MS patients with high and normal BMI received clinical and MRI evaluation. Blood samples were...

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PMID: 30981648
DOI: 10.1016/j.ebiom.2019.03.087

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