Article
Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1.
PloS one - 1 Jan 2019
Pfister Jason A, Ma Chi, D'Mello Santosh R
Abstract excerpt
SIRT1, a NAD+-dependent deacetylase, protects neurons in a variety of in vitro and in vivo models of neurodegenerative disease. We have previously described a neuroprotective effect by SIRT1 independent of its catalytic activity. To confirm this conclusion we tested a panel of SIRT1 deletion mutant constructs, designated Δ1-Δ10, in cerebellar granule neurons induced to undergo apoptosis by low potassium...
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