Article
Silent information regulator 1 protects the brain against cerebral ischemic damage.
Stroke - 1 Aug 2013
Hernández-Jiménez Macarena, Hurtado Olivia, Cuartero María I, Ballesteros Iván, Moraga Ana, Pradillo Jesús M, McBurney Michael W, Lizasoain Ignacio, Moro María A
Abstract excerpt
BACKGROUND AND PURPOSE: Sirtuin 1 (SIRT1) is a member of NAD+-dependent protein deacetylases implicated in a wide range of cellular functions and has beneficial properties in pathologies including ischemia/reperfusion processes and neurodegeneration. However, no direct evidence has been reported on the direct implication of SIRT1 in ischemic stroke. The aim of this study was to establish the role of SIRT1 in...
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