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Article

SirT1 fails to affect p53-mediated biological functions.

Aging cell - 1 Feb 2006

Kamel Christopher, Abrol Meena, Jardine Karen, He Xiaohong, McBurney Michael W

Abstract excerpt

The SirT1 gene encodes a protein deacetylase that acts on a number of nuclear substrates. p53 was identified as a SirT1 substrate whose transcriptional activity was reported to be negatively regulated by SirT1-dependent deacetylation. We set out to determine whether developmental defects and perinatal lethality observed in SirT1-null mice were caused by p53 hyperactivity by creating mice deficient for both SirT1...

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Identifiers

PMID: 16441846
DOI: 10.1111/j.1474-9726.2006.00191.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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