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Article

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.

Molecular brain - 29 Aug 2014

Watanabe Seiji, Ageta-Ishihara Natsumi, Nagatsu Shinji, Takao Keizo, Komine Okiru, Endo Fumito, Miyakawa Tsuyoshi, Misawa Hidemi, Takahashi Ryosuke, Kinoshita Makoto, Yamanaka Koji

Abstract excerpt

BACKGROUND: Dominant mutations in superoxide dismutase 1 (SOD1) cause degeneration of motor neurons in a subset of inherited amyotrophic lateral sclerosis (ALS). The pathogenetic process mediated by misfolded and/or aggregated mutant SOD1 polypeptides is hypothesized to be suppressed by protein refolding. This genetic study is aimed to test whether mutant SOD1-mediated ALS pathology recapitulated in mice could be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25167838
DOI: 10.1186/s13041-014-0062-1
PMCID: PMC4237944

Genes

SIRT1
SOD1
HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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