Article
ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations.
Toxins - 14 Feb 2021
Moral-Sanz Javier, Fernandez-Rojo Manuel A, Potriquet Jeremy, Mukhopadhyay Pamela, Brust Andreas, Wilhelm Patrick, Smallwood Taylor B, Clark Richard J, Fry Bryan G, Alewood Paul F, Waddell Nicola, Miles John J, Mulvenna Jason P, Ikonomopoulou Maria P
Abstract excerpt
Melanoma is the main cause of skin cancer deaths, with special emphasis in those cases carrying BRAF mutations that trigger the mitogen-activated protein kinases (MAPK) signaling and unrestrained cell proliferation in the absence of mitogens. Current therapies targeting MAPK are hindered by drug resistance and relapse that rely on metabolic rewiring and Akt activation. To identify new drug candidates against...
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