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Article

Role of mitochondria and potential of mitochondria-targeted therapy in BRAF mutant cancer: A review.

Critical reviews in oncology/hematology - 1 Nov 2024

Gao Yanyan, Zheng Hua

Abstract excerpt

The classical mitogen-activated protein kinase (MAPK) signaling pathway, the Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK protein kinase cascade, is a conserved cascade that regulates cell growth, differentiation, and proliferation. The significance of BRAF in cancer was established with the discovery of cancer-activating mutations in BRAF in several human tumors in 2002. Currently, BRAF is...

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PMID: 39197669
DOI: 10.1016/j.critrevonc.2024.104484

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