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Article

Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

4 Apr 2019

Abstract excerpt

Paralysis occurring in amyotrophic lateral sclerosis (ALS) results from denervation of skeletal muscle as a consequence of motor neuron degeneration. Interactions between motor neurons and glia contribute to motor neuron loss, but the spatiotemporal ordering of molecular events that drive these processes in intact spinal tissue remains poorly understood. Here, we use spatial transcriptomics to obtain gene...

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PMID: 30948552
DOI: 10.1126/science.aav9776

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