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Article

The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis.

Cell reports - 14 Jul 2015

Ikiz Burcin, Alvarez Mariano J, Ré Diane B, Le Verche Virginia, Politi Kristin, Lotti Francesco, Phani Sudarshan, Pradhan Radhika, Yu Changhao, Croft Gist F, Jacquier Arnaud, Henderson Christopher E, Califano Andrea, Przedborski Serge

Abstract excerpt

Neurodegenerative phenotypes reflect complex, time-dependent molecular processes whose elucidation may reveal neuronal class-specific therapeutic targets. The current focus in neurodegeneration has been on individual genes and pathways. In contrast, we assembled a genome-wide regulatory model (henceforth, "interactome"), whose unbiased interrogation revealed 23 candidate causal master regulators of...

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Identifiers

PMID: 26146077
DOI: 10.1016/j.celrep.2015.06.019
PMCID: PMC4646662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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