Article

Limitations of Current Machine-Learning Models in Predicting Enzymatic Functions for Uncharacterized Proteins

2024-07-03

Abstract excerpt

Thirty to seventy percent of proteins in any given genome have no assigned function and have been labeled as the protein “unknome”. This large knowledge shortfall is one of the final frontiers of biology. Machine-Learning (ML) approaches are enticing, with early successes demonstrating the ability to propagate functional knowledge from experimentally characterized proteins. An open question is the ability of machi...

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Literature Corpus work: a3ad196a-5e68-59b9-b267-43087e23474b
DOI: 10.1101/2024.07.01.601547

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