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Article

Exosomal miRNA Cargo as Mediator of Immune Escape Mechanisms in Neuroblastoma

1 Apr 2019

Abstract excerpt

Abstract Both natural killer (NK) cells and exosomes released from these cells induce tumor cell cytotoxicity by way of the cell killing proteins perforin and granzyme. TGFβ1 protein in the tumor microenvironment generates an immune escape mechanism rendering NK cells inactive. The tumor-suppressive miR-186 that is downregulated in neuroblastoma and in TGFβ-treated NK cells represses oncogenic proteins in...

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PMID: 30936073
DOI: 10.1158/0008-5472.can-19-0021

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