Article

Potassium channels mediate the inhibitory effect of exosomes on anti-tumor immunity in head and neck cancer

2025-07-28

Abstract excerpt

Head and neck squamous cell carcinomas (HNSCC) are aggressive cancers with a relatively low response rate to immunotherapy. Anti-tumor immune responses rely on cytotoxic T and NK cells infiltrating the tumor microenvironment to eliminate cancer cells. However, tumors activate multiple mechanisms to evade these responses. Tumor-derived small extracellular vesicles, also known as exosomes, reshape the tumor microenv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2540f892-b27b-5218-93df-c1b0a04788ba
DOI: 10.1101/2025.07.25.666838

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Potassium channels mediate the inhibitory effect of exosomes on anti-tumor immunity in head and neck cancerDOI 10.1101/2025.07.25.666838Read

Suppression of Lymphocyte Functions by Plasma Exosomes Correlates with Disease Activity in Patients with Head and Neck CancerSemantic proximity Read

Roles of Cancer Exosomes in Immunosuppression and Immune EvasionSemantic proximity Read

Cancer extracellular vesicles as novel regulators of NK cell response.Semantic proximity Read

Involvement of extracellular vesicles in the macrophage-tumor cell communication in head and neck squamous cell carcinoma.Semantic proximity Read

Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulationSemantic proximity Read

Exosomes: Mediators of cellular communication in potentially malignant oral lesions and head and neck cancersSemantic proximity Read

NK Cell-derived Exosomes From NK Cells Previously Exposed to Neuroblastoma Cells Augment the Antitumor Activity of Cytokine-activated NK Cells.Semantic proximity Read

Tumor-derived exosomes induce CD8+ T cell suppressorsSemantic proximity Read

Potential oncogenic roles of mutant-p53-derived exosomes in the tumor-host interaction of head and neck cancers.Semantic proximity Read

Exosomal miRNA Cargo as Mediator of Immune Escape Mechanisms in NeuroblastomaSemantic proximity Read

Natural Killer–Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape MechanismsSemantic proximity Read

An Immunosuppressive Effect of Melanoma-derived Exosomes on NY-ESO-1 Antigen-specific Human CD8+ T Cells is Dependent on IL-10 and Independent of BRAFV600E Mutation in Melanoma Cell Lines.Semantic proximity Read