EZH2 inhibition enhances NK cell-mediated cytotoxicity and potentiates anti-GD2 immunotherapy in neuroblastoma

Abstract excerpt

<title>Abstract</title> <p> Neuroblastoma (NB) is the commonest extracranial childhood cancer with devastating prognosis for patients who relapse after intensive maintenance treatment. Although EZH2 inhibitors can enhance the tumour immune microenvironment in adult cancers, the mechanisms by which EZH2 improves immunotherapy remain poorly understood. Analysis of publicly available gene expression datasets from N...

Topics

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• CAR-T cell therapy research
• Drug Resistance, Neoplasm
• Enhancer of Zeste Homolog 2 Protein
• Epigenetics and DNA Methylation
• Gene Expression Regulation, Neoplastic
• Molecular Targeted Therapy
• Mutation
• Neuroblastoma Research and Treatments

Identifiers and source

Literature Corpus work

214c57d8-3b6d-500f-999c-d2bb8955ddd9

DOI

10.21203/rs.3.rs-10502198/v1