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Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer

16 Aug 2023

Abstract excerpt

The therapeutic efficacy of metformin in prostate cancer (PCa) appears uncertain based on various clinical trials. Metformin treatment failure may be attributed to the high frequency of transcriptional dysregulation, which leads to drug resistance. However, the underlying mechanism is still unclear. In this study, we found evidences that metformin resistance in PCa cells may be linked to cell cycle reactivation....

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PMID: 37582751
DOI: 10.1038/s41392-023-01516-2

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