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Article

Molecular pathways of kidney development and their applications to clinical research.

Kidney international - 1 Feb 2026

Ehrhart Friederike, Martens Helge, Rosenblum Norman D, Schedl Andreas, Schlesinger Thorben A, Gjerstad Ann Christin, Haffner Dieter, Ho Jacqueline, Evelo Chris T, Woolf Adrian S, Weber Ruthild G, Schaefer Franz

Abstract excerpt

Congenital anomalies of the kidney and urinary tract (CAKUT) are the major cause of childhood chronic kidney disease and an antecedent cause of adult-onset cardiovascular and kidney failure. Both genetic and environmental factors have been implicated in human kidney malformations, with pathogenic variants or DNA copy number variations identified in ∼16% and 10% of cases, respectively. To date, >60...

Read the complete abstract on PubMed

Topics

Humans
Kidney
Organogenesis
Signal Transduction
Urogenital Abnormalities
Machine Learning

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Expression Regulation, Developmental

Animals

Translational Research, Biomedical

Genetic Predisposition to Disease

Vesico-Ureteral Reflux

Source

Identifiers

PMID: 41271103
DOI: 10.1016/j.kint.2025.09.032

Genes

GDNF
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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