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Article

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis

27 Mar 2019

Abstract excerpt

Chronic hepatitis B is one of the world’s unconquered diseases with more than 240 million infected subjects at risk of developing liver disease and hepatocellular carcinoma. Hepatitis B virus reverse transcribes pre-genomic RNA to relaxed circular DNA (rcDNA) that comprises the infectious particle. To establish infection of a naïve target cell, the newly imported rcDNA is repaired by host enzymes to generate...

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Identifiers

PMID: 30918010
DOI: 10.26508/lsa.201900355

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