Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-6, IL-12, and IL-23 STAT-Pathway Genetic Risk and Responsiveness of Lymphocytes in Patients with Multiple Sclerosis

26 Mar 2019

Abstract excerpt

Multiple sclerosis (MS) is an immune-mediated demyelinating disease characterized by central nervous system (CNS) lymphocyte infiltration, abundant production of pro-inflammatory cytokines, and inappropriate activation of Th1 and Th17 cells, B cells, and innate immune cells. The etiology of MS is complex, and genetic factors contribute to disease susceptibility. Genome-wide association studies (GWAS) have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Multiple Sclerosis Research Studies
Share to Psoriasis: Treatment and Pathogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30917537
DOI: 10.3390/cells8030285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-6, IL-12, and IL-23 STAT-Pathway Genetic Risk and Responsiveness of Lymphocytes in Patients with Multiple SclerosisPMID 30917537Read ↗

Identification of blood-derived candidate gene markers and a new 7-gene diagnostic model for multiple sclerosisSemantic proximity Read ↗

Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis.Semantic proximity Read ↗

Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis.Semantic proximity Read ↗

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling.Semantic proximity Read ↗

TLR3 polymorphism protects against multiple sclerosis onset but not progression in Egyptian patients.Semantic proximity Read ↗

Impact of coding risk variant IFNGR2 on the B cell-intrinsic IFN-γ signaling pathway in multiple sclerosis.Semantic proximity Read ↗

GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosisSemantic proximity Read ↗

Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4Semantic proximity Read ↗

STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility.Semantic proximity Read ↗

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.Semantic proximity Read ↗

Interferon gamma allelic variants: sex-biased multiple sclerosis susceptibility and gene expression.Semantic proximity Read ↗

Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.