Article
Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.
Human genetics - 1 Mar 2010
Zuvich Rebecca L, McCauley Jacob L, Oksenberg Jorge R, Sawcer Stephen J, De Jager Philip L, Aubin Cristin, Cross Anne H, Piccio Laura, Aggarwal Neelum T, Evans Denis, Hafler David A, Compston Alastair, Hauser Stephen L, Pericak-Vance Margaret A, Haines Jonathan L
Abstract excerpt
Multiple sclerosis (MS) is characterized as an autoimmune demyelinating disease. Numerous family studies have confirmed a strong genetic component underlying its etiology. After several decades of frustrating research, the advent and application of affordable genotyping of dense SNP maps in large data sets has ushered in a new era in which rapid progress is being made in our understanding of the genetics...
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