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Article

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling.

PLoS genetics - 1 Oct 2020

Lundtoft Christian, Pucholt Pascal, Imgenberg-Kreuz Juliana, Carlsson-Almlöf Jonas, Eloranta Maija-Leena, Syvänen Ann-Christine, Nordmark Gunnel, Sandling Johanna K, Kockum Ingrid, Olsson Tomas, Rönnblom Lars, Hagberg Niklas

Abstract excerpt

Interferons (IFNs) are cytokines that are central to the host defence against viruses and other microorganisms. If not properly regulated, IFNs may contribute to the pathogenesis of inflammatory autoimmune, or infectious diseases. To identify genetic polymorphisms regulating the IFN system we performed an unbiased genome-wide protein-quantitative trait loci (pQTL) mapping of cell-type specific type I and type II...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-gamma

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Source

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Identifiers

PMID: 33104735
DOI: 10.1371/journal.pgen.1009199
PMCID: PMC7644105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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