Impact of coding risk variant IFNGR2 on the B cell-intrinsic IFN-γ signaling pathway in multiple sclerosis.

doi:10.1016/j.jaut.2024.103279

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Article

Impact of coding risk variant IFNGR2 on the B cell-intrinsic IFN-γ signaling pathway in multiple sclerosis.

Journal of autoimmunity - 1 Sept 2024

Bogers Laurens, Rip Jasper, Rijvers Liza, van Langelaar Jamie, Koetzier Steven C, Kuiper Kirsten L, Meerdink Veronique, Wierenga-Wolf Annet F, Melief Marie-José, Marques Ana M, Smolders Joost, van Luijn Marvin M

Abstract excerpt

B cells of people with multiple sclerosis (MS) are more responsive to IFN-γ, corresponding to their brain-homing potential. We studied how a coding single nucleotide polymorphism (SNP) in IFNGR2 (rs9808753) co-operates with Epstein-Barr virus (EBV) infection as MS risk factors to affect the IFN-γ signaling pathway in human B cells. In both cell lines and primary cells, EBV infection positively associated with...

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PMID: 38972102
DOI: 10.1016/j.jaut.2024.103279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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