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Article

Single‐cell molecular profiling provides a high‐resolution map of basophil and mast cell development

20 Oct 2020

Abstract excerpt

BACKGROUND: Basophils and mast cells contribute to the development of allergic reactions. Whereas these mature effector cells are extensively studied, the differentiation trajectories from hematopoietic progenitors to basophils and mast cells are largely uncharted at the single-cell level. METHODS: We performed multicolor flow cytometry, high-coverage single-cell RNA sequencing analyses, and cell fate assays to...

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PMID: 33078414
DOI: 10.1111/all.14633

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