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Article

Molecular basis of the little mouse phenotype and implications for cell type-specific growth.

Nature - 15 Jul 1993

Lin S C, Lin C R, Gukovsky I, Lusis A J, Sawchenko P E, Rosenfeld M G

Abstract excerpt

The molecular basis for the little (lit) mouse phenotype, characterized by a hypoplastic anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the growth hormone releasing factor receptor. Detailed analysis of the lit mouse anterior pituitary reveals spatially distinct proliferative zones of growth hormone-producing stem cells and mature somatotrophs, each regulated by a...

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PMID: 8391647
DOI: 10.1038/364208a0

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Molecular basis of the little mouse phenotype and implications for cell type-specific growth.PMID 8391647Read ↗

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