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Article

Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.

PLoS pathogens - 1 Jan 2018

Alandijany Thamir, Roberts Ashley P E, Conn Kristen L, Loney Colin, McFarlane Steven, Orr Anne, Boutell Chris

Abstract excerpt

Detection of viral nucleic acids plays a critical role in the induction of intracellular host immune defences. However, the temporal recruitment of immune regulators to infecting viral genomes remains poorly defined due to the technical difficulties associated with low genome copy-number detection. Here we utilize 5-Ethynyl-2'-deoxyuridine (EdU) labelling of herpes simplex virus 1 (HSV-1) DNA in combination with...

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Topics

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Share to Cell Line, Transformed
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpes Simplex

Share to Herpesvirus 1, Human

Share to Lysogeny

Share to Promyelocytic Leukemia Protein

Share to Reverse Transcriptase Inhibitors

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 29309427
DOI: 10.1371/journal.ppat.1006769
PMCID: PMC5757968

Genes

PML
IFI16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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