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Article

Physiological loading of joints prevents cartilage degradation through CITED2.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2011

Leong Daniel J, Li Yong H, Gu Xiang I, Sun Li, Zhou Zuping, Nasser Philip, Laudier Damien M, Iqbal Jameel, Majeska Robert J, Schaffler Mitchell B, Goldring Mary B, Cardoso Luis, Zaidi Mone, Sun Hui B

Abstract excerpt

Both overuse and disuse of joints up-regulate matrix metalloproteinases (MMPs) in articular cartilage and cause tissue degradation; however, moderate (physiological) loading maintains cartilage integrity. Here, we test whether CBP/p300-interacting transactivator with ED-rich tail 2 (CITED2), a mechanosensitive transcriptional coregulator, mediates this chondroprotective effect of moderate mechanical loading. In...

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Share to Joints
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cartilage, Articular

Share to Hydrostatic Pressure

Share to p300-CBP Transcription Factors

Share to Proto-Oncogene Protein c-ets-1

Share to Restraint, Physical

Share to Tissue Culture Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 20826544
DOI: 10.1096/fj.10-164277
PMCID: PMC3005439

Genes

CITED2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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