Article

CD14 plays a critical role in pain and inflammation across multiple models of post-traumatic osteoarthritis

2025-06-05

Abstract excerpt

Inflammation is a primary driver of osteoarthritis (OA), and no therapies exist to halt or delay disease progression or substantially ameliorate the chronic pain, inflammation and disability that are characteristic of disease. Soluble CD14 (sCD14), a co-factor that enhances inflammatory toll-like receptor signaling, is present in synovial fluid in patients with OA and positively associates with joint space narrowi...

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Literature Corpus work: 30c7b788-5a95-54e5-9e41-274fe71ac4b6
DOI: 10.1101/2025.06.02.657478

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