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Article

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression

29 Aug 2015

Abstract excerpt

Fetal hemoglobin (HbF, α2γ2) induction is a well-validated strategy for sickle cell disease (SCD) treatment. Using a small-molecule screen, we found that UNC0638, a selective inhibitor of EHMT1 and EHMT2 histone methyltransferases, induces γ-globin expression. EHMT1/2 catalyze mono- and dimethylation of lysine 9 on histone 3 (H3K9), raising the possibility that H3K9Me2, a repressive chromatin mark, plays a role...

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PMID: 26320100
DOI: 10.1182/blood-2015-06-649087

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