Article
Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages.
Scientific reports - 20 Feb 2018
Pang Shichao, Sun Yidi, Wu Leilei, Yang Liguang, Zhao Yi-Lei, Wang Zhen, Li Yixue
Abstract excerpt
Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evolution of KIRC were primarily associated with SNVs, we reconstructed an evolutionary process of KIRC using cross-sectional...
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