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Article

Determinants of Receptor- and Tissue-Specific Actions in Androgen Signaling

8 Jun 2015

Abstract excerpt

The physiological androgens testosterone and 5α-dihydrotestosterone regulate the development and maintenance of primary and secondary male sexual characteristics through binding to the androgen receptor (AR), a ligand-dependent transcription factor. In addition, a number of nonreproductive tissues of both genders are subject to androgen regulation. AR is also a central target in the treatment of prostate cancer....

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Share to Estrogen and related hormone effects
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 26052734
DOI: 10.1210/er.2015-1034

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